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This Concept Map, created with IHMC CmapTools, has information related to: Patho Cmap, antibiotic use decreases normal flora, prostaglandins stimulates Pain (epigastric and sternal), releasing cytokines release serotonin, soluble fragments leads to Inflammation, C. albicans adhere to endothelia cell suface causes endocytosis of C. albicans by endothelial cells, CD4+ molecule on helper T cell leads to RNA converts into DNA using reverse transcriptase, ingests pathogen and debris results in phagocyte rupture, Cleavage of several proteins produces soluble fragments, Down regulation of MHC class II expression in Antigen Presenting Cells (such as Macrophages, dendritic cells, and B cells decreases antigen presentation, decreased plasma cells leads to cell-mediated immunity, phagocyte rupture releasing debris, Endothelial Cell Damage causes inactivation of Nitric Oxide, direct viral killing of infected cells leads to low levels of CD4+ T cells, Phagocytes causes ingests pathogen and debris, Mast Cells degranulate releasing Histamine, injury to other cells causes Lesions, loss of vasodilation (local) causes Local ischemia (decreased perfusion), debris results in superficial plaque on buccal surface, gum, and tongue, Mast Cells degranulate relasing chemotactic factors, Lesions causes difficulty eating